Study Uncovers How Exercise Combats Osteoporosis

Osteoporosis is a disease that makes bones weak and affects millions worldwide. Important discoveries may lead to new treatments after scientists found how exercise strengthens bones.

Researchers at the University of Hong Kong found that a special protein, called Piezo1, helps bones grow when we exercise. This finding is important because it may help fight osteoporosis, a condition that causes fragile bones.

The study focused on cells in bone marrow that can become either bone cells or fat cells. Exercise influences these cells to become bone cells. The protein acts as an “exercise sensor” for the bones, promoting growth and reducing fat.

When Piezo1 was removed in mice, their bones weakened, showing more fat. Without this protein, they didn’t get the exercise benefits. Scientists could reverse these effects by activating Piezo1, suggesting it could be used in future treatments.

“This discovery shows how movement makes bones stronger,” says scientist Xu Aimin. By targeting Piezo1, it’s possible to mimic exercise benefits without actual movement, which could help those who can’t exercise.

However, treatments are still far away, as this research was in mice. Piezo1 is involved in many body functions, so targeting it needs caution to avoid side effects. Yet, this is a crucial step in understanding osteoporosis, especially as more people live longer.

Eric Honoré, a researcher from France, states this approach could slow bone loss and protect those unable to move, reducing fracture risks. The study was published in “Signal Transduction and Targeted Therapy.”