Saturday, September 13, 2025

Large Animals: Cancer Risk vs. Evolutionary Defenses

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Some researchers from University College London have discovered that bigger animals, like elephants and whales, have evolved genes that help them resist cancer better than smaller animals. This means that despite having more cells that could develop cancer, larger animals actually have a lower risk of the disease. This finding challenges a long-standing idea called Peto’s paradox.

In their study of 263 species, the scientists found that for every 1% increase in body mass, there was only a small increase in cancer rate. This suggests that larger species have developed more ways to protect themselves against cancer over time. For example, elephants and whales have genetic adaptations that enhance DNA repair and prevent abnormal cell growth.

Understanding how these animals resist cancer could lead to new treatments for humans. By targeting specific biological pathways that protect against cancer in these animals, scientists hope to develop more effective therapies. These potential treatments could be highly promising because they are based on mechanisms that have evolved over millions of years.

Further research in this area could revolutionize cancer treatment and prevention, offering hope for the future.

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Vocabulary List:

  1. Species /ˈspiː.ʃiːz/ (noun): A group of living organisms consisting of similar individuals capable of exchanging genes or interbreeding.
  2. Evolution /ˌiː.vəˈluː.ʃən/ (noun): The gradual development of something especially from a simple to a more complex form.
  3. Adaptations /ˌædæpˈteɪʃənz/ (noun): Changes or processes that allow an organism to better survive in its environment.
  4. Mechanisms /ˈmɛk.ə.nɪ.zəmz/ (noun): Processes by which something occurs or is carried out.
  5. Therapies /ˈθɛr.ə.piz/ (noun): Treatments intended to relieve or heal a disorder.
  6. Resistance /rɪˈzɪs.təns/ (noun): The ability not to be affected by something such as a disease.

How much do you know?

According to the researchers from University College London, what characteristic do bigger animals like elephants and whales possess in terms of cancer resistance?
They have fewer cells that could develop cancer
They have lower overall body mass
They have evolved genes that help resist cancer better than smaller animals
They have a higher risk of cancer
What concept is challenged by the finding that larger animals have a lower risk of cancer despite having more cells?
Darwin's theory of evolution
Peto’s paradox
The theory of relativity
The law of gravity
How many species were included in the study conducted by the scientists?
102 species
185 species
263 species
325 species
What do elephants and whales have that enhance DNA repair and prevent abnormal cell growth according to the text?
Genetic adaptations
Extra body weight
More body fat
Higher metabolic rate
What could potentially lead to new treatments for humans according to the text?
Studying fish genetics
Exploring outer space
Understanding how animals resist cancer
Developing new smartphones
Why are the potential treatments based on mechanisms that have evolved over millions of years considered highly promising?
Because they are based on guesswork
Because they involve expensive technologies
Because they are based on proven evolutionary adaptations
Because they are purely theoretical
Bigger animals like elephants and whales have evolved genes that help them resist cancer better than smaller animals.
The scientists found that for every 1% increase in body mass, there was a significant increase in cancer rate.
The researchers believe that understanding how animals resist cancer could have no implications for humans.
Potential treatments based on mechanisms that have evolved over millions of years are not considered promising by scientists.
The study conducted by the scientists involved 102 species only.
Peto’s paradox is a concept that remains unchallenged by the researchers.
By targeting specific biological pathways that protect against cancer in these animals, scientists hope to develop more effective .
Potential treatments for cancer that are based on mechanisms evolving over millions of years are highly .
Further research in this area could revolutionize cancer treatment and .
For every 1% increase in body mass, there was only a small increase in cancer rate across the 263 included in the study.
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