The medications Ozempic and Wegovy, both containing the glucagon-like peptide 1 receptor agonist semaglutide, have been highly successful for Novo Nordisk, with sales doubling and reaching $1.35 billion in 2024. Despite their popularity, research has shown that these drugs may come with serious risks, such as gastrointestinal issues and potential vision problems.
A recent study published in JAMA Ophthalmology highlighted a possible link between semaglutide and non-arteritic anterior ischemic optic neuropathy (NAION), a condition that can lead to sudden blindness. The study revealed a significant increase in the risk of NAION among diabetic or overweight individuals using semaglutide compared to other medications.
Furthermore, other studies have indicated a connection between semaglutide and retinopathy, particularly in individuals with uncontrolled Type 2 diabetes. It has been suggested that taking semaglutide may increase the risk of retinopathy complications, including blindness.
Additionally, the use of GLP-1 receptor agonists, like semaglutide, has been linked to various adverse effects, such as gastroparesis, biliary disease, pancreatitis, and bowel obstruction. These drugs have also been associated with metabolic, nutritional, urinary, cardiac, and eye disorders.
To address weight loss more safely and effectively, it may be beneficial to focus on enhancing the expression of GLP-1 receptors rather than inhibiting them. This can be achieved through the consumption of polyphenol-rich foods that support gut health and the growth of beneficial bacteria like Akkermansia muciniphila.
Furthermore, natural compounds like berberine, found in certain plants, have shown promise in supporting weight loss and managing conditions like Type 2 diabetes. By minimizing the intake of linoleic acid, commonly found in seed oils and processed foods, individuals can promote healthier weight loss outcomes and reduce the risk of chronic health issues associated with medications like Ozempic and Wegovy.
Vocabulary List:
- Glucagon /ˈɡluː.kə.ɡɒn/ (noun): A hormone involved in glucose metabolism and regulation.
- Ischemic /ɪˈskiː.mɪk/ (adjective): Relating to a restriction in blood supply causing a shortage of oxygen.
- Retinopathy /ˌrɛtɪˈnɒpəθi/ (noun): A disease of the retina that can result in vision impairment.
- Biliary /ˈbɪl.i.ər.i/ (adjective): Relating to the bile ducts or bile.
- Gastroparesis /ˌɡæstroʊpəˈriːsɪs/ (noun): A condition that reduces the ability of the stomach to empty its contents.
- Polyphenol /ˌpɒliˈfiː.nɒl/ (noun): A type of antioxidant compound found in plants that has health benefits.
How much do you know?
