Spinach Eye Drops May Treat Common Eye Condition

Scientists at the National University of Singapore have adapted photosynthesis, the process plants use to convert sunlight into energy, to treat dry eye syndrome. This condition, causing discomfort to over a billion people globally, might soon have a new treatment option.

Researchers have used photosynthetic components from spinach, applying them as eye drops to human and mice eye cells with dry eye disease. When exposed to light, these components started producing NADPH. This molecule acts like a chemical battery, helping cells fight harmful damage.

NADPH plays a key role in reducing reactive oxygen species (ROS), which cause inflammation and stress in dry eye syndrome. Early results are promising, suggesting that the soreness of dry eyes might be eased through this light-powered solution.

This innovation, named LEAF—light-reaction enriched thylakoid NADPH-foundry—uses components of chloroplasts, the structures responsible for photosynthesis in plants. Spinach was selected for its high chloroplast yield and easy extraction process, making it a cost-effective choice.

In tests, NADPH generated by light reduced ROS activity and helped corneal cells return to a protective state. This approach also showed success with tears from patients suffering from dry eye, decreasing harmful oxidants significantly.

LEAF has potential beyond dry eye treatment, possibly aiding other inflammatory conditions by protecting tissues exposed to light. Though human trials are next, and more research is needed, especially for long-term effects, preparations for clinical trials are underway.

The study was published in the journal Cell.

How much do you know?

What is the purpose of the LEAF innovation?

To treat dry eye syndrome

To improve photosynthesis in plants

To develop new types of eye drops

To increase spinach production

Which component from spinach was used in the treatment?

Chlorophyll

NADPH

Glucose

Water

What is the full name of the LEAF innovation?

Light-Energy Adapted Formula

Light-Reaction Enhanced Aqueous Fluid

Light-Reaction Enriched Thylakoid NADPH-Foundry

Light-Emitting Aqueous Foundry

What role does NADPH play in the treatment for dry eye syndrome?

It generates light

It acts like a chemical battery

It absorbs carbon dioxide

It enhances tear production

What condition is being treated with the LEAF innovation?

Dry eye syndrome

Conjunctivitis

Glaucoma

Cataract

Which journal published the study on the LEAF innovation?

Science

Nature

Cell

Journal of Eye Research

The LEAF innovation uses components from spinach to treat dry eye syndrome.

True False

Human trials for the LEAF treatment have already been completed.

True False

NADPH helps reduce reactive oxygen species (ROS) in dry eye syndrome.

True False

The LEAF innovation is only designed for eye treatments.

True False

Spinach was chosen for its low chloroplast yield.

True False

Research for the LEAF innovation is still ongoing.

True False

The LEAF innovation adapts to treat dry eye syndrome.

NADPH acts like a chemical battery, helping cells fight harmful .

The study suggests that the treatment of dry eyes could be eased through a solution.

In tests, NADPH generated by light reduced ROS activity and helped corneal cells return to a state.

The LEAF innovation utilizes components of , the structures responsible for photosynthesis.

Preparations for clinical trials of the LEAF innovation are .

This question is required