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The neurotransmitter serotonin, known for managing mood, may also affect the severity of tinnitus, according to new research. Tinnitus is often described as a noise, like ringing or hissing, that only the patient can hear.
Scientists in the US and China conducted a study on mice. They found that increasing serotonin signals in a particular brain area made tinnitus-like symptoms worse. This is important because serotonin is usually targeted to help with depression and anxiety. This study could help create treatments that improve mood without worsening tinnitus.
The researchers discovered a connection between serotonin and the auditory system, which processes sound. When they switched off this circuit in mice, the tinnitus-like symptoms decreased. The study explains how activity in certain brain areas relates to the symptoms of tinnitus.
Researchers used light and drugs to see how serotonin affected the mice. When activated, the mice behaved as if they were hearing sounds that were not there.
This research shows a real link between serotonin and tinnitus. It highlights the need for careful treatment when managing depression or anxiety in patients who also have tinnitus. New drugs could help separate the helpful effects of antidepressants from negative effects on hearing.