Tuesday, March 24, 2026

Weight loss drug linked to suicide risk poses safety concerns.

Editor’s Note: If you or someone you know is feeling very sad or having thoughts of hurting themselves, please call the 988 Suicide & Crisis Lifeline by dialing 988 to talk to someone who can help, or visit the 988 Lifeline website.

A recent study looked at people taking a medication called semaglutide for diabetes and weight loss. Some people taking this medication reported thinking about hurting themselves more than those taking other drugs. However, other studies have different opinions on whether these medications can cause these feelings.

Semaglutide, sold as Ozempic and Wegovy, has been linked to a risk of suicidal thoughts. But experts are still unsure if the medication directly causes these thoughts. People who take antidepressants along with semaglutide might have an increased risk of mood changes.

Experts suggest being cautious when prescribing appetite-suppressing medications like GLP-1 to patients with a history of depression. If a patient experiences new feelings of sadness while on the medication, doctors may consider stopping it. It’s important to gather more information to better understand these risks.

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Vocabulary List:
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Semaglutide/ˌsɛməˈɡluːtaɪd/noun
A medication used for the treatment of diabetes and weight loss.

Suicidal/ˌsuːɪˈsaɪdəl/adjective
Having thoughts or feelings of wanting to harm oneself.

Depression/dɪˈprɛʃən/noun
A mental health disorder characterized by persistently low mood and loss of interest.

Antidepressants/ˌæntiˈdɪprɛsənts/noun
Medications used to treat depression and anxiety disorders.

Appetite-suppressing/ˈæpɪtaɪt səˈprɛsɪŋ/adjective
Referring to substances that reduce the desire to eat.

Experts/ˈɛkspɜːrts/noun
People with specialized knowledge or skill in a particular area.

How much do you know?

What medication was studied in relation to diabetes and weight loss?
A) Insulin
B) Semaglutide
C) Metformin
D) Aspirin
What are the brand names under which semaglutide is sold?
A) Insulogic and Thinvict
B) Ozempic and Wegovy
C) Glucagen and Fitrex
D) Pancrevive and Slimdex
What are experts unsure about regarding semaglutide and suicidal thoughts?
A) The link between semaglutide and suicidal thoughts
B) If semaglutide directly causes suicidal thoughts
C) The absence of any risks associated with semaglutide
D) The positive effects of semaglutide on mental health
Which group of individuals might have an increased risk of mood changes when taking antidepressants along with semaglutide?
A) Children
B) Elderly
C) People with diabetes
D) People taking antidepressants
What caution is advised by experts when prescribing appetite-suppressing medications like GLP-1?
A) Higher dosages in patients with a history of depression
B) No restrictions as the benefits outweigh the risks
C) Close monitoring in patients with a history of depression
D) Immediate discontinuation in all cases
When might doctors consider stopping the medication for a patient experiencing new feelings of sadness?
A) Immediately upon any mood changes
B) After a week of consistent symptoms
C) If the feelings persist and worsen
D) Never as it's considered a normal side effect
This question is required

Test Your Understanding

Start Quiz
Vocabulary List:
6 words · tap to reveal
OFF
AccentSpeed
Semaglutide/ˌsɛməˈɡluːtaɪd/noun
A medication used for the treatment of diabetes and weight loss.
Suicidal/ˌsuːɪˈsaɪdəl/adjective
Having thoughts or feelings of wanting to harm oneself.
Depression/dɪˈprɛʃən/noun
A mental health disorder characterized by persistently low mood and loss of interest.
Antidepressants/ˌæntiˈdɪprɛsənts/noun
Medications used to treat depression and anxiety disorders.
Appetite-suppressing/ˈæpɪtaɪt səˈprɛsɪŋ/adjective
Referring to substances that reduce the desire to eat.
Experts/ˈɛkspɜːrts/noun
People with specialized knowledge or skill in a particular area.

How much do you know?

What medication was studied in relation to diabetes and weight loss?
A) Insulin
B) Semaglutide
C) Metformin
D) Aspirin
What are the brand names under which semaglutide is sold?
A) Insulogic and Thinvict
B) Ozempic and Wegovy
C) Glucagen and Fitrex
D) Pancrevive and Slimdex
What are experts unsure about regarding semaglutide and suicidal thoughts?
A) The link between semaglutide and suicidal thoughts
B) If semaglutide directly causes suicidal thoughts
C) The absence of any risks associated with semaglutide
D) The positive effects of semaglutide on mental health
Which group of individuals might have an increased risk of mood changes when taking antidepressants along with semaglutide?
A) Children
B) Elderly
C) People with diabetes
D) People taking antidepressants
What caution is advised by experts when prescribing appetite-suppressing medications like GLP-1?
A) Higher dosages in patients with a history of depression
B) No restrictions as the benefits outweigh the risks
C) Close monitoring in patients with a history of depression
D) Immediate discontinuation in all cases
When might doctors consider stopping the medication for a patient experiencing new feelings of sadness?
A) Immediately upon any mood changes
B) After a week of consistent symptoms
C) If the feelings persist and worsen
D) Never as it's considered a normal side effect
This question is required

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